Identify your use: cocktail, syrup, or baked dessert—this changes whether you prioritize alcohol burn, sweetness, or pure orange aroma.
Pick the closest match from the ranked list, then start with the swap ratio for that substitute.
If the substitute is sweeter than cointreau (many triple secs), reduce sweetness elsewhere (e.g., less sugar/syrup) or add a touch more lime/lemon in cocktails.
If the substitute tastes too bitter or too boozy, dilute slightly with citrus juice (drinks) or add a bit more fat/base (baking) to smooth it out.
Taste once you’ve mixed your full batch; adjust in small increments so you don’t overshoot the balance.