Pick the closest substitute based on your dish: DIY soy+vinegar+sugar for general cooking, anchovy+lemon for maximum umami, or ketchup+soy+vinegar for stews.
Use the listed ratio as your starting point, then add small adjustments: more vinegar for tang, a pinch more sugar for balance, or a tiny splash of water to thin.
Taste at the stage your recipe can still adapt (before baking finishes or before the sauce reduces too far).
If the substitute is saltier than worcestershire, reduce the amount slightly and compensate with water or broth to keep the texture.
For baking, start with the substitute and keep an eye on browning—more sugar can darken faster.