Preheat the oven to 400°F (200°C). Line a baking sheet with parchment paper.
In a mixing bowl, combine panko breadcrumbs, parmesan cheese, garlic powder, paprika, salt, and melted butter. Stir until well mixed.
Pat the tilapia fillets dry and season lightly with salt and pepper.
Press the fillets into the panko mixture, coating the top side evenly.
Place the coated fillets on the prepared baking sheet and bake for 12-15 minutes, or until the crust is golden and the fish flakes easily with a fork.
Serve immediately with fresh parsley and lemon wedges.