Identify your use: baking (cake/cookie), glaze/sauce, or a finishing drizzle; choose the substitute closest to that behavior.
Match sweetness first: start with the 1:1 ratio, then reduce honey/liqueur base if the batter or sauce turns overly sticky.
Add citrus aroma if needed: mix in a small amount of orange zest for DIY whisky/cognac swaps to mimic drambuie’s lift.
Adjust thickness: if the substitute is thinner than drambuie, let the sauce simmer briefly (or bake longer) to concentrate.
Taste after cooking: for baking, check near the end of bake time; for sauces, taste off-heat and fine-tune with a tiny pinch of salt or more honey.